basic medical sciences

Life, a love story

life, a love story
One day there were two brothers, Dyno and Ryno, who had one sister, Pyra. The three were so much good and loved each other so much. They enjoyed their lives playing, singing and discovering. The only thing that was disturbing for them is that they were endangered by many instabilities and accidents happening here and there without the least sign or warning. They were therefore not a few times seen crying and excited. The three could however catch themselves and play, sing and discover.

Dyno was the least active among the three but also the most patient and decent. Ryno was midway between Dyno and Pyra. The latter being the most active, courageous and clever. The two boys and the girl were therefore much consolidated and could complete each other. The roles were well assigned to each member. Pyra was probing everything she sees and touches, Ryno redoes what Pyra shown him with almost great affinity, and Dyno writes down the notice with a wonderful hand writing and illustration. The record was increasing day after day and the three lovers’ enthusiasm and excitement was growing too.

Pyra was so much proud of her discovery “the glycolysis soup”. She could earn her two brothers forever as they shared it together in a wonderful evening where all stars in the sky were so big and bright. Ryno could make himself little useful by reminding Pyra that it was he who helped her understand the essence of her irresistible soup. Dyno on the other hand by his decentness and provocative patience had no need to compliment himself. Pyra was for the two boys the wonder that made their lives meaningful and living worthy. Not only fascinated by the receipts she can discover and formulate but also by the amazing plays, games and tricks that shocked them sometimes.

They were spending much time playing in their wind-speedy circle that they called Krebs cycle after the name of a story they liked of their mom. Pyra discovered a track like a double way rail which they agreed to call glycolysis which was also connected by very amusing chamber of lusty experience which they named hexose monophosphate headway. While running in the Krebs cycle they tasted a sour taste of different degrees which was much tricky and pleasant than any similar taste in the many snacks that Pyra could make. They had only to take care not to fall out of the circle into a fool smelling square named the urea niche.

In this way enjoyed the three good kids their lives, playing, singing and discovering. Their pleasure rises and their fear rises too because of the endless dangers they see around them. In a calm night when the sky was clear and full of big and shiny stars they sat thinking how to protect themselves and the super wonderful life they could grasp and enjoy.

Pyra: I cannot help myself any more when I just imagine that we may not be here in just a blink of an eye.
Ryno: yes, you have right dear Pyra. It is very painful like that.
Pyra: You, Dyno. Don’t you have an idea?
Dyno: Of course there should be an idea, Pyra, even we do not know it for now. I think it would be a well deserved gift for you as you made our lives so meaningful and living worthy. There should be an idea.
Pyra: thank you for your optimism, Dyno. You are a wonderful brother too.
Ryno: you both are so kind. I may have found it. Pyra, you are the best discoverer and Dyno is the best archive clerk. Do not you see that we have every rule and every matter around us so finely and wisely defined and set? We have only to find the way how to perpetuate these settings including ourselves so that our lives extend and the fun and joy we made stand for as long as it could be.
Pyra: Great, Ryno. I guess your talent is toady in peak form.
Ryno: Very fortunately, dear Pyra. As Dyno has just said, it would be a well deserved gift for you.

The three kids took a deep breath, relaxed their bodies and closed their eyes. Wonderful silence filled the scene except for the shines of star light blessing the kids roaming in the seek for the life they liked. They opened their eyes in the same moment, smiled in the faces of each other and said: let’s do it.

Pyra: eeeh my dear Dyno, my dear Ryno!
Ryno: yes, the best Pyra I have ever known.
Dyno: the notices I have here wish to be blown!
Pyra: mais, no. mais, no. the cell is drawn.
Ryno: the cell will be two, the two be four!
Dyno: so nice, the notices I have are just and more.
I am here just for this honor!
Ryno: I am too, will serve in the labor.
And make the fun reach every place.
Pyra: so nice, I am proud of you both.
And I will never be tired to play and roar!
Pyra, Ryno and Dyno: live long life and let our love reach every place.

basic medical sciences

A note on the emergence of Biochemistry


Human knowledge is cumulative in nature so that siblings inherit knowledge and experiences from their parents and ancestors. However, it is not until those unfounded myths and ideas are replaced by evidence-based information and concepts that our lives improve and advance. This statement is correct for the “phlogiston” and the “vital force” theories that would – if not debunked by Lavoisier and Wöhler, respectively – stuck our perception for chemistry up till now.

Lavoisier (1743 – 1794) could show in hand of self made equipments such as relatively fair balances that the mass of reactants must equal that of products in a given chemical change, i.e. law of conservation of mass. In this way defeated Lavoisier the very popular idea in his time that matter could be gained or lost during chemical reaction as a vague concept named phlogiston was accused for this argument. Notably during analysis of the combustion phenomenon, Lavoisier had, in the contrary, constructed his experiments so that all the materials could be accounted for during and after the reaction. By this law deserved Lavoisier the name as father of modern chemistry. Wöhler (1800 – 1882) could for the first time synthesize urea (an organic substance known to happen in living organisms only, i.e. in vivo) from inorganic substances, namely ammonia and cyanic acid, in the laboratory, i.e. in vitro. This achievement by Wöhler demolished the idea that organic substances can happen only inside living organism thanks to a mysterious vital force. By this way opened Wöhler a wonderful discipline to courageously study and investigate the matter of the living world, i.e. Biochemistry.

It came then to realize that the matter of the livings not only can be reliably studied by the same means as exactly as the nonliving matter could be but also it obeys the same rules and laws of the nonliving matter. Such fact was founded by some physicists such as Bohr (1885 – 1962), Schrödinger (1887 – 1961), and Max Delbrück (1906 – 1981). Delbrück grounded a group called the Phage Group that believed that their bacteriophage model (bacterial virus) bears much hope to unravel crucial rules in studying the genetic material. Again, we are at the door of a new fascinating world of Molecular Biology.

After this very brief introduction we would see that Biochemistry is a relatively new discipline that concerns everything about living matter at the level of molecules and atoms. We owe our knowledge in Biochemistry to chemists and physicists, as mentioned above, and to biologists as well. The generalization by Schleiden and Schwann in 1839 that all living organisms are made of small structural and functional units called cells, i.e. the cell theory, has made possible all subsequent progresses in our Biology and Biochemistry. It is then worthy noting that none of the scientific disciplines is independent of the others, e.g., when physicists ground for Molecular Biology and mathematicians for Biostatistics and Gene Banks and Bioinformatics.

Useful references:

–          TA Brown, Genetics, a molecular approach, 3. Edition, Stanley Thornes (Publishers) Ltd.

–          Online Wikipedia.